Erythrocyte Metabolism
نویسنده
چکیده
Previous studies from this laboratory on the preservation of erythrocytes stored in vitro have shown that the storage lesion, as characterized by the decline in level of organic phosphate esters, may be reversed by incubating the aged cells with certain purine nucleosides (1). Pyrimidine nucleosides were ineffective in this respect, as was the addition of the purine bases and ribose, alone or in combination. These observations, together with the fact that reincorporation of inorganic phosphate’ into the organic phosphate fractions paralleled the restoration of viability (2), suggested that the initial reaction was being carried out by a purine nucleoside phosphorylase,
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